BRCT domain

BRCA1 C Terminus (BRCT) domain

Structure of an XRCC1 BRCT domain.^[1]

Identifiers

Symbol

BRCT

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins.

The BRCT domain (after the C_terminal domain of a breast cancer susceptibility protein) is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage,^[2] for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.^[3]

Examples

Human proteins containing this domain include:

References

^ Zhang X, Moréra S, Bates PA, et al. (November 1998). "Structure of an XRCC1 BRCT domain: a new protein-protein interaction module". EMBO J. 17 (21): 6404–11. doi:10.1093/emboj/17.21.6404. PMC 1170965. PMID 9799248. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1170965.
^ Bork P, Hofmann K, Koonin EV, Bucher P, Neuwald AF, Altschul SF (1997). "A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins". FASEB J. 11 (1): 68–76. PMID 9034168.
^ Chen J, Yu X, Mer G, He M, Chini CC (2003). "The BRCT domain is a phospho-protein binding domain". Science 302 (5645): 639–642. doi:10.1126/science.1088753. PMID 14576433.

External links

Eukaryotic Linear Motif resource motif class LIG_BRCT_BRCA1_1
Eukaryotic Linear Motif resource motif class LIG_BRCT_BRCA1_2
Eukaryotic Linear Motif resource motif class LIG_BRCT_MDC1_1

This article incorporates text from the public domain Pfam and InterPro IPR001357